I’ve always been fascinated by the role of genetics in sport. Obviously, there’s the heredity aspect that sometimes helps children of great athletes become great athletes themselves. More practically for those who don’t win the DNA lottery, genes affect the way individuals respond to stimuli, potentially opening the door to even greater customization of training, nutrition, and recovery interventions. The use of genetic insights in sports is currently, and will continue to be, a hotly debated topic among coaches and sport scientists. To get first-hand experience with it, I sent a saliva sample to Helix to see what insights I could glean from my own genetic profile.
The Endurance DNA product CTS created in partnership with Helix currently provides insights on 20 genetic variants thought to affect endurance athletic performance. The process is pretty simple. You get a sample kit in the mail, provide a saliva sample, and mail the package back. You then receive an email informing you that your profile is available, and you log in to your account to view your results.
I’m not going to go through all 20 of the insights from my profile, but there were a few big takeaways from my data:
Osteoarthritis: Higher Risk
According to my genetic profile, I am predisposed to a higher risk of developing osteoarthritis. While once thought to be primarily the result of wear and tear, a more updated view is that it’s a degenerative disorder affecting cartilage, and excessive use or trauma can accelerate or exacerbate it. On the flip side, there’s the notion that regular exercise improves joint health by keeping lubricating synovial fluid circulating in the joint capsule.
In my case, I suffered significant trauma to the bones and cartilage in my knee when I broke my femur. I split the femoral condyles, ended up with a one-inch shorter leg, and subsequently had multiple knee surgeries. Thirty years later and after tens of thousands of miles on the bike, even that damaged knee does not show signs of osteoarthritis. If anything, the results of my genetic profile affirm my belief that regular exercise and thoroughly rehabbing injuries are essential components of maintaining healthy joints.
Bone Density: Higher
For those people who think I’m hard-headed, you might be right! I am genetically predisposed to have higher bone density, and despite a lifetime of predominantly non-weight bearing exercise, tests show my bones are okay. My bone density is slightly below average but still comparable to the overall average for men my age.
There is some evidence longtime cyclists, especially those who chronically restrict energy intake to maintain a low bodyweight, may be at increased risk for low bone density and increased risk for fractures. I was that athlete for about 15 years, including my late teens and early twenties when I was still reaching peak bone density. I have broken plenty of bones during my life, but only from very traumatic accidents. I’d like to think that the combination of a varied diet containing enough calcium, a genetic predisposition to high bone density, and incorporating strength training after turning 40 has helped me get this far with healthy and sturdy bones.
Electrolytes: Typical Sodium and Low Magnesium
Muscle cramps were once thought to be caused primarily from electrolyte imbalances, but we now know electrolyte levels in the blood is just one of several factors that contribute to cramping, or may not influence cramping at all. I’ve always had a problem with muscle cramps during very long and very hot rides, which is when there is definitely a bigger overall stress on the body as a combination of muscular fatigue, dehydration, and low electrolyte levels.
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My genetic predispositions for typical sodium and low magnesium levels in the blood is not indicative of a major problem, but it does provide some context to why I might be more vulnerable to cramps than others. Though I sometimes consume saltier foods and incorporate electrolyte-rich sports drinks into my nutrition strategy for long training rides and ultraendurance events, knowing my genetic predisposition encourages me to use an electrolyte-rich strategy more consistently.
No Huge Red Flags
Perhaps the best thing about my genetic profile is what it doesn’t say. We incorporated an ‘Insights Dashboard” into Endurance DNA because it’s important to take a step back and look at the broad overview of your genetic profile. Individual insights are important, but what does the constellation of insights infer about your overall risks or opportunities?
Applying and tailoring the recommendations to an individual’s training and goals is why we incorporated a CTS Coaching Consultation into Endurance DNA. In my case, my profile includes a relatively low number of areas where my genetics put me at increased risk for injury, nutrient deficiency, or hindered endurance performance. Similarly, it doesn’t infer that I’m an outlier with the potential for superhuman performance and perfect health.
The results are realistic and – notably – don’t contain any insights wildly contrary to my personal experience. For instance, in the multivariate insight that compares your genetic markers to a database of elite athletes, I didn’t rank all that high compared to the best endurance athletes. Even though I was a pro cyclist, I felt that was true. When I got really light I was pretty good, but even then it was on the 3-5 minute climbs, maybe the 10 minute ones. On the long climbs on big mountain stages I always felt like my engine was two cylinders short compared to the best.
Would Genetic Information Change The Way I Coach?
This is the big question, and a big part of the reason I wanted to experience getting my own profile. The results of a genetic test do not change the fundamental building blocks or principles of endurance training. If I were coaching an athlete with my exact genetic results who was training as an endurance cyclist, I’d keep the fundamentals of their annual plan the same. I would use the genetic profile as a guide and try to find ways to test whether we could take advantage of genetic predispositions that could improve performance and perhaps prevent injury. The profile would also alert me to areas I should keep an eye on because they might be vulnerabilities.
In my view, genetic testing adds another layer of data we can use to generate a more complete picture of an athlete. We already have data from power meters, heart rate monitors, wearable sensors, lactate threshold and VO2 max tests, and many more. One of the values of genetic information is that it’s a leading indicator, providing information on what to look out for or what opportunities you might want to pursue. This is in contrast to information from power meters and wearable sensors are lagging indicators. Each piece of data is important on its own, but it’s more important as a part of that complete athlete profile. After all, we coach the whole athlete and the whole person, not just individual performance markers.
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